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Freeze-Dried Injectable Products: Mannitol is commonly used as a bulking agent in freeze-dried injectable products. It increases the cake mass and prevents blowout during the freeze-drying process, resulting in a mechanically robust and pharmaceutically elegant lyophile.

Oral Dispersible and Chewable Tablets: Mannitol is the filler of choice for orally dispersible and chewable tablets due to its high solubility, pleasant taste, and mouthfeel. It provides a cool sensation when dissolved in the mouth and does not raise blood glucose levels or have a laxative effect.

Freeze-Drying: Mannitol can be used as a cryoprotector in freeze-drying processes, helping to maintain the stability and integrity of biological molecules during the freezing and drying steps.

Nasal and Pulmonary Delivery Systems: Mannitol is used as a drug carrier in nasal and pulmonary delivery systems, facilitating the penetration of drugs through biological barriers.

Direct Compression: Mannitol is available in various grades suitable for direct compression, providing good flowability and the ability to produce mechanically resistant tablets.

Wet Granulation: In wet granulation processes, mannitol improves the stability and properties of granules. It is partly solubilized by the granulation liquid and recrystallizes upon drying, enhancing the stability and consistency of the granules.